like so?

$date = "<p><strong>April 1</strong></p>
  <ul>
  <li>New Jersey has received an additional <strong>3,649 </strong>positive test results, bringing the total number of positive 
test results to <strong>22,255</strong></li>"

$info = (((($date) -split "<strong>") -replace "covid-19", "") -replace "\D+", "")
$info[2]

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