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Fibrin ring granulomas in hepatitis A

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Summary

Fibrin ring granuloma is characterized by a fibrinous ring surrounding a central fat vacuole. It has been found in the liver and bone marrow of patients with Q fever, and occasionally with visceral leishmaniasis, cytomegalovirus, Epstein-Barr virus,Staphylococcus epidermidis infections, Hodgkin's lymphoma, and hypersensitivity to allopurinol. We describe a case of serologically confirmed viral hepatitis A with this lesion in the liver biopsy. A false positive anti-hepatitis A virus IgM result has been excluded. This is, to our knowledge, the second reported case of type A hepatitis with hepatic fibrin ring granulomas. It confirms that hepatitis A should be included in the differential diagnosis of this lesion.

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Authors and Affiliations

  1. Médecine interne et gastro-entérologie, Hôpital de Senlis, BP 121, F 60309, Senlis, Cedex, France

    M. Ruel MD, H. Sevestre MD, E. Henry-Biabaud MD, A. M. Courouce PhD, J. P. Capron MD & S. Erlinger MD

  2. Anatomie pathologique, C.H.R.U., F 80054, Amiens, Cedex, France

    M. Ruel MD, H. Sevestre MD, E. Henry-Biabaud MD, A. M. Courouce PhD, J. P. Capron MD & S. Erlinger MD

  3. Institut National de Transfusion sanguine, 6, Rue Alexandre Cabanel, F 75739, Paris, Cedex 15, France

    M. Ruel MD, H. Sevestre MD, E. Henry-Biabaud MD, A. M. Courouce PhD, J. P. Capron MD & S. Erlinger MD

  4. Hépato-gastro-entérologie, C.H.R.U., F 80054, Amiens, Cedex, France

    M. Ruel MD, H. Sevestre MD, E. Henry-Biabaud MD, A. M. Courouce PhD, J. P. Capron MD & S. Erlinger MD

  5. Hépatologie, C.H.U. Beaujon, F 92118, Clichy, Cedex, France

    M. Ruel MD, H. Sevestre MD, E. Henry-Biabaud MD, A. M. Courouce PhD, J. P. Capron MD & S. Erlinger MD

Authors
  1. M. Ruel MD
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  2. H. Sevestre MD
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  3. E. Henry-Biabaud MD
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  4. A. M. Courouce PhD
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  5. J. P. Capron MD
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  6. S. Erlinger MD
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Ruel, M., Sevestre, H., Henry-Biabaud, E. et al. Fibrin ring granulomas in hepatitis A. Digest Dis Sci 37, 1915–1917 (1992). https://doi.org/10.1007/BF01308088

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  • DOI: https://doi.org/10.1007/BF01308088

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