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Review
. 2021 Aug 31:12:626553.
doi: 10.3389/fmicb.2021.626553. eCollection 2021.

Animal Models for COVID-19: Hamsters, Mouse, Ferret, Mink, Tree Shrew, and Non-human Primates

Shuyu Shou  1 , Menghui Liu  1 , Yang Yang  1 , Ning Kang  1 , Yingying Song  1 , Dan Tan  1 , Nannan Liu  1 , Feifei Wang  1 , Jing Liu  1 , Youhua Xie  1   2
Affiliations
Review

Animal Models for COVID-19: Hamsters, Mouse, Ferret, Mink, Tree Shrew, and Non-human Primates

Shuyu Shou et al. Front Microbiol. .

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus causing acute respiratory tract infection in humans. The virus has the characteristics of rapid transmission, long incubation period and strong pathogenicity, and has spread all over the world. Therefore, it is of great significance to select appropriate animal models for antiviral drug development and therapeutic effect evaluation. Here, we review and compare the current animal models of SARS-CoV-2.

Keywords: ACE2 (angiotensin converting enzyme 2); COVID-19; SARS-CoV-2; animal model; pathogenesis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Phylogenetic analysis of ACE2 orthologs of 12 species and crucial ACE2 residues at the interface with the viral S protein. National Center for Biotechnology Information (NCBI) accession numbers for ACE2 are as follows: NP_001358344.1 (human), XP_008987241.1 (marmoset), XP_027288607.1 (Chinese hamster), XP_005593094 (cynomolgus macaque), NP_001129168.1 (rhesus macaque), XP_005074266.1 (Syrian hamster), NP_001123985.1 (mouse), BAE53380.1 (ferret), QPL12211.1 (mink), QPL07045.1 (Roborovski dwarf hamster), XP_006164754.1 (tree shrew), and AAY57872.1 (African green monkey) were analyzed and the phylogenetic tree was accomplished by MGEA-X (version 10.0.5). The 20 amino acid residues at the interface between human ACE2 and SARS-CoV-2 RBD are shown on the right (Shang et al., 2020). Each amino acid is identified by a different color.
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