Entry - *609472 - CYCLIC NUCLEOTIDE-GATED CHANNEL, ALPHA-4; CNGA4 - OMIM - (OMIM.ORG)

 
 
* 609472

CYCLIC NUCLEOTIDE-GATED CHANNEL, ALPHA-4; CNGA4


HGNC Approved Gene Symbol: CNGA4

Cytogenetic location: 11p15.4   Genomic coordinates (GRCh38) : 11:6,234,793-6,244,976 (from NCBI)


TEXT

▼ Description

CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001).


▼ Biochemical Features

Zheng and Zagotta (2004) found that when cRNA for 3 rat olfactory CNG channel subunits, Cnga2 (300338), Cnga4, and Cngb1b (CNGB1; 600724), were coinjected into Xenopus oocytes, functional channels in the surface membrane contained a fixed ratio of Cnga2:Cnga4:Cngb1b of 2:1:1. When expressed individually with Cnga2, the Cnga4 and Cngb1b subunits were present as single copies, and when expressed alone, they did not self-assemble.


▼ Animal Model

Munger et al. (2001) found that olfactory epithelium and olfactory bulb developed normally in Cnga4-null mice. Expression of olfactory marker mRNA and protein (OMP; 164340), which is associated with mature olfactory receptor neurons, was also normal. Electroolfactograms recorded from mutant animals suggested that odor perception was not affected by Cnga4 deletion, but mutant animals showed a defect in odor adaptation. Odorant channels in excised membrane patches from Cnga4-null mice exhibited decreased affinity for cAMP and slower Ca(2+)-calmodulin (see 114180)-mediated channel desensitization. Munger et al. (2001) concluded that the CNGA4 subunit accelerates the Ca(2+)-mediated negative feedback in olfactory signaling and allows rapid adaptation in this sensory system.


▼ REFERENCES

  1. Munger, S. D., Lane, A. P., Zhong, H., Leinders-Zufall, T., Yau, K.-W., Zufall, F., Reed, R. R. Central role of the CNGA4 channel subunit in Ca(2+)-calmodulin-dependent odor adaptation. Science 294: 2172-2175, 2001. [PubMed: 11739959, images, related citations] [Full Text]

  2. Zheng, J., Zagotta, W. N. Stoichiometry and assembly of olfactory cyclic nucleotide-gated channels. Neuron 42: 411-421, 2004. [PubMed: 15134638, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 7/12/2005
Edit History:
mgross : 03/19/2013
terry : 3/12/2013
terry : 3/12/2013
mgross : 7/12/2005

* 609472

CYCLIC NUCLEOTIDE-GATED CHANNEL, ALPHA-4; CNGA4


HGNC Approved Gene Symbol: CNGA4

Cytogenetic location: 11p15.4   Genomic coordinates (GRCh38) : 11:6,234,793-6,244,976 (from NCBI)


TEXT

Description

CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001).


Biochemical Features

Zheng and Zagotta (2004) found that when cRNA for 3 rat olfactory CNG channel subunits, Cnga2 (300338), Cnga4, and Cngb1b (CNGB1; 600724), were coinjected into Xenopus oocytes, functional channels in the surface membrane contained a fixed ratio of Cnga2:Cnga4:Cngb1b of 2:1:1. When expressed individually with Cnga2, the Cnga4 and Cngb1b subunits were present as single copies, and when expressed alone, they did not self-assemble.


Animal Model

Munger et al. (2001) found that olfactory epithelium and olfactory bulb developed normally in Cnga4-null mice. Expression of olfactory marker mRNA and protein (OMP; 164340), which is associated with mature olfactory receptor neurons, was also normal. Electroolfactograms recorded from mutant animals suggested that odor perception was not affected by Cnga4 deletion, but mutant animals showed a defect in odor adaptation. Odorant channels in excised membrane patches from Cnga4-null mice exhibited decreased affinity for cAMP and slower Ca(2+)-calmodulin (see 114180)-mediated channel desensitization. Munger et al. (2001) concluded that the CNGA4 subunit accelerates the Ca(2+)-mediated negative feedback in olfactory signaling and allows rapid adaptation in this sensory system.


REFERENCES

  1. Munger, S. D., Lane, A. P., Zhong, H., Leinders-Zufall, T., Yau, K.-W., Zufall, F., Reed, R. R. Central role of the CNGA4 channel subunit in Ca(2+)-calmodulin-dependent odor adaptation. Science 294: 2172-2175, 2001. [PubMed: 11739959] [Full Text: https://doi.org/10.1126/science.1063224]

  2. Zheng, J., Zagotta, W. N. Stoichiometry and assembly of olfactory cyclic nucleotide-gated channels. Neuron 42: 411-421, 2004. [PubMed: 15134638] [Full Text: https://doi.org/10.1016/s0896-6273(04)00253-3]


Creation Date:
Patricia A. Hartz : 7/12/2005

Edit History:
mgross : 03/19/2013
terry : 3/12/2013
terry : 3/12/2013
mgross : 7/12/2005



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2025 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2025 Johns Hopkins University.
Printed: June 19, 2025