* 609665
NLR FAMILY, PYRIN DOMAIN-CONTAINING 14; NLRP14
Alternative titles; symbols
NACHT DOMAIN-, LEUCINE-RICH REPEAT-, AND PYD-CONTAINING PROTEIN 14; NALP14
NOD5
HGNC Approved Gene Symbol: NLRP14
Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38) : 11:7,020,446-7,090,900 (from NCBI)
TEXT
Description
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP14, have an N-terminal pyrin (MEFV; 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).
Cloning and Expression
Tschopp et al. (2003) stated that the 993-amino acid NALP14 protein has the typical PYD-NACHT-LRR domain structure found in the NALP family. Inohara and Nunez (2003) also reported the NALP14 gene, which they called NOD5.
Mapping
Tschopp et al. (2003) stated that the NALP14 gene maps to chromosome 11p15.4.
REFERENCES
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Inohara, N., Nunez, G. NODs: intracellular proteins involved in inflammation and apoptosis. Nature Rev. Immun. 3: 371-382, 2003. [PubMed: 12766759] [Full Text: https://doi.org/10.1038/nri1086]
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Tschopp, J., Martinon, F., Burns, K. NALPs: a novel protein family involved in inflammation. Nature Rev. Molec. Cell Biol. 4: 95-104, 2003. [PubMed: 12563287] [Full Text: https://doi.org/10.1038/nrm1019]
carol : 6/3/2009
alopez : 12/4/2008
carol : 6/27/2007
mgross : 10/19/2005