Review
doi: 10.1016/j.jcv.2005.09.004.
Epub 2005 Sep 29.
Basics of the virology of HIV-1 and its replication
Affiliations
- PMID: 16198625
- DOI: 10.1016/j.jcv.2005.09.004
Item in Clipboard
Review
Basics of the virology of HIV-1 and its replication
J Clin Virol.
2005 Dec.
Abstract
Human immunodeficiency virus is undoubtedly the causative agent of AIDS. The understanding of HIV-1 pathogenesis is essential to develop and maintain antiretroviral treatment and vaccination. Since the first isolation of HIV-1 in cell culture, thousands of publications dealing with HIV and/or AIDS per year were released. In this review we give a basic overview of the virology of HIV-1 including the functions of the different HIV-1 proteins required for effective viral replication. Moreover, we summarize the interactive processes between HIV-1 and its target cells. Finally, the HIV-1 specific immune response and the current status of antiretroviral therapy are briefly described in this review.
Similar articles
-
HIV-1 dynamics in vivo: implications for therapy.Nat Rev Microbiol. 2003 Dec;1(3):181-90. doi: 10.1038/nrmicro772. Nat Rev Microbiol. 2003. PMID: 15035022 Review.
-
Therapeutic vaccination against HIV: current progress and future possibilities.Clin Sci (Lond). 2006 Jan;110(1):59-71. doi: 10.1042/CS20050157. Clin Sci (Lond). 2006. PMID: 16336205 Review.
-
The interaction of HIV-1 with the host factors.Jpn J Infect Dis. 2005 Jun;58(3):125-30. Jpn J Infect Dis. 2005. PMID: 15973003 Review.
-
Chromatin-associated regulation of HIV-1 transcription: implications for the development of therapeutic strategies.Subcell Biochem. 2007;41:371-96. Subcell Biochem. 2007. PMID: 17484137 Review.
-
Latency: the hidden HIV-1 challenge.Retrovirology. 2006 Jan 16;3:7. doi: 10.1186/1742-4690-3-7. Retrovirology. 2006. PMID: 16412247 Free PMC article. Review.
Cited by
-
HIV-1 Latency and Latency Reversal: Does Subtype Matter?Viruses. 2019 Nov 28;11(12):1104. doi: 10.3390/v11121104. Viruses. 2019. PMID: 31795223 Free PMC article. Review.
-
High-speed atomic force microscopy directly visualizes conformational dynamics of the HIV Vif protein in complex with three host proteins.J Biol Chem. 2020 Aug 21;295(34):11995-12001. doi: 10.1074/jbc.RA120.014442. Epub 2020 Jun 24. J Biol Chem. 2020. PMID: 32587092 Free PMC article.
-
HIV-1 and the immune response to TB.Future Virol. 2013 Jan;8(1):57-80. doi: 10.2217/fvl.12.123. Future Virol. 2013. PMID: 23653664 Free PMC article.
-
2D and 3D QSAR studies of diarylpyrimidine HIV-1 reverse transcriptase inhibitors.J Comput Aided Mol Des. 2008 Nov;22(11):831-41. doi: 10.1007/s10822-008-9217-4. Epub 2008 May 28. J Comput Aided Mol Des. 2008. PMID: 18506577
-
Increased levels of human beta-defensins mRNA in sexually HIV-1 exposed but uninfected individuals.Curr HIV Res. 2008 Nov;6(6):531-8. doi: 10.2174/157016208786501463. Curr HIV Res. 2008. PMID: 18991618 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
