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. 2006:26:154-8.

The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas

Edward F McCarthy  1
Affiliations

The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas

Edward F McCarthy. Iowa Orthop J. 2006.

Abstract

In 1891, William B. Coley injected streptococcal organisms into a patient with inoperable cancer. He thought that the infection he produced would have the side effect of shrinking the malignant tumor. He was successful, and this was one of the first examples of immunotherapy. Over the next forty years, as head of the Bone Tumor Service at Memorial Hospital in New York, Coley injected more than 1000 cancer patients with bacteria or bacterial products. These products became known as Coley's Toxins. He and other doctors who used them reported excellent results, especially in bone and soft-tissue sarcomas. Despite his reported good results, Coley's Toxins came under a great deal of criticism because many doctors did not believe his results. This criticism, along with the development of radiation therapy and chemotherapy, caused Coley's Toxins to gradually disappear from use. However, the modern science of immunology has shown that Coley's principles were correct and that some cancers are sensitive to an enhanced immune system. Because research is very active in this field, William B. Coley, a bone sarcoma surgeon, deserves the title "Father of Immunotherapy".

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Figures

Figure 1
Figure 1
William B. Coley (1862-1936) from Trans Am Surg Assoc 54(1936):415. Courtesy of the Welch Library of the History of Medicine.
Figure 2
Figure 2
Drawing of Coley's first bone sarcoma case treated with his toxins. Courtesy of Annals of Surgery/Lippincott.
Figure 3
Figure 3
Title page to Coley's first article of 1891 describing his toxins. Courtesy of Annals of Surgery/Lippincott.
See this image and copyright information in PMC

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