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. 2013 Jan 20;435(2):201-9.
doi: 10.1016/j.virol.2012.10.002. Epub 2012 Oct 23.

Evidence for negative-strand RNA virus infection in fungi

Hideki Kondo  1 , Sotaro Chiba, Kazuhiro Toyoda, Nobuhiro Suzuki
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Free article

Evidence for negative-strand RNA virus infection in fungi

Hideki Kondo et al. Virology. .
Free article

Abstract

Fungal viruses comprise two groups: a major group of five families with double-stranded RNA genomes and a minor group with positive-sense single-stranded (ss)RNA genomes. Although many fungal viruses have been identified, no negative-stranded (-)ssRNA mycoviruses have been reported. Here we present two lines of evidence suggesting the presence of (-)ssRNA viruses in filamentous fungi based on an exhaustive search using extant (-)ssRNA viruses as queries. This revealed (-)ssRNA virus L protein-like sequences in the genome of a phytopathogenic obligate ascomycete, Erysiphe pisi. A similar search for (-)ssRNA viruses in fungal transcriptome shotgun assembly libraries demonstrated that two independent libraries from Sclerotinia homoeocarpa, another phytopathogenic ascomycete, contained several sequences considered to correspond to the entire mononegavirus L gene and likely originating from an infecting (-)ssRNA virus. These results provide strong evidence for both ancient and extant (-)ssRNA virus infections in fungi.

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