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Meta-Analysis
. 2018 Dec 24;12(12):CD006205.
doi: 10.1002/14651858.CD006205.pub4.

Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment

Vishal M Bulsara  1 , Helen V Worthington, Anne-Marie Glenny, Janet E Clarkson, David I Conway, Michaelina Macluskey
Affiliations
Meta-Analysis

Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment

Vishal M Bulsara et al. Cochrane Database Syst Rev. .

Update in

Abstract

Background: Surgery is an important part of the management of oral cavity cancer with regard to both the removal of the primary tumour and removal of lymph nodes in the neck. Surgery is less frequently used in oropharyngeal cancer. Surgery alone may be treatment for early-stage disease or surgery may be used in combination with radiotherapy, chemotherapy and immunotherapy/biotherapy. There is variation in the recommended timing and extent of surgery in the overall treatment regimens of people with these cancers. This is an update of a review originally published in 2007 and first updated in 2011.

Objectives: To determine which surgical treatment modalities for oral and oropharyngeal cancers result in increased overall survival, disease-free survival and locoregional control and reduced recurrence. To determine the implication of treatment modalities in terms of morbidity, quality of life, costs, hospital days of treatment, complications and harms.

Search methods: Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (to 20 December 2017), the Cochrane Central Register of Controlled Trials (CENTRAL; 2017, Issue 11), MEDLINE Ovid (1946 to 20 December 2017) and Embase Ovid (1980 to 20 December 2017). We searched the US National Institutes of Health Trials Registry (ClinicalTrials.gov) and the World Health Organization International Clinical Trials Registry Platform for ongoing trials. There were no restrictions on the language or date of publication.

Selection criteria: Randomised controlled trials where more than 50% of participants had primary tumours of the oral cavity or oropharynx, or where separate data could be extracted for these participants, and that compared two or more surgical treatment modalities, or surgery versus other treatment modalities.

Data collection and analysis: Two or more review authors independently extracted data and assessed risk of bias. We contacted study authors for additional information as required. We collected adverse events data from included studies.

Main results: We identified five new trials in this update, bringing the total number of included trials to 12 (2300 participants; 2148 with cancers of the oral cavity). We assessed four trials at high risk of bias, and eight at unclear. None of the included trials compared different surgical approaches for the excision of the primary tumour. We grouped the trials into seven main comparisons.Future research may change the findings as there is only very low-certainty evidence available for all results.Five trials compared elective neck dissection (ND) with therapeutic (delayed) ND in participants with oral cavity cancer and clinically negative neck nodes, but differences in type of surgery and duration of follow-up made meta-analysis inappropriate in most cases. Four of these trials reported overall and disease-free survival. The meta-analyses of two trials found no evidence of either intervention leading to greater overall survival (hazard ratio (HR) 0.84, 95% confidence interval (CI) 0.41 to 1.72; 571 participants), or disease-free survival (HR 0.73, 95% CI 0.25 to 2.11; 571 participants), but one trial found a benefit for elective supraomohyoid ND compared to therapeutic ND in overall survival (RR 0.40, 95% CI 0.19 to 0.84; 67 participants) and disease-free survival (HR 0.32, 95% CI 0.12 to 0.84; 67 participants). Four individual trials assessed locoregional recurrence, but could not be meta-analysed; one trial favoured elective ND over therapeutic delayed ND, while the others were inconclusive.Two trials compared elective radical ND with elective selective ND, but we were unable to pool the data for two outcomes. Neither study found evidence of a difference in overall survival or disease-free survival. A single trial found no evidence of a difference in recurrence.One trial compared surgery plus radiotherapy with radiotherapy alone, but data were unreliable because the trial stopped early and there were multiple protocol violations.One trial comparing positron-emission tomography-computed tomography (PET-CT) following chemoradiotherapy (with ND only if no or incomplete response) versus planned ND (either before or after chemoradiotherapy), showed no evidence of a difference in mortality (HR 0.92, 95% CI 0.65 to 1.31; 564 participants). The trial did not provide usable data for the other outcomes.Three single trials compared: surgery plus adjunctive radiotherapy versus chemoradiotherapy; supraomohyoid ND versus modified radical ND; and super selective ND versus selective ND. There were no useable data from these trials.The reporting of adverse events was poor. Four trials measured adverse events. Only one of the trials reported quality of life as an outcome.

Authors' conclusions: Twelve randomised controlled trials evaluated ND surgery in people with oral cavity cancers; however, the evidence available for all comparisons and outcomes is very low certainty, therefore we cannot rely on the findings. The evidence is insufficient to draw conclusions about elective ND of clinically negative neck nodes at the time of removal of the primary tumour compared to therapeutic (delayed) ND. Two trials combined in meta-analysis suggested there is no difference between these interventions, while one trial (which evaluated elective supraomohyoid ND) found that it may be associated with increased overall and disease-free survival. One trial found elective ND reduced locoregional recurrence, while three were inconclusive. There is no evidence that radical ND increases overall or disease-free survival compared to more conservative ND surgery, or that there is a difference in mortality between PET-CT surveillance following chemoradiotherapy versus planned ND (before or after chemoradiotherapy). Reporting of adverse events in all trials was poor and it was not possible to compare the quality of life of people undergoing different surgical treatments.

PubMed Disclaimer

Conflict of interest statement

VB: none known. HW: none known. I am a Co‐ordinating Editor of Cochrane Oral Health. AMG: none known. I am Deputy Co‐ordinating Editor of Cochrane Oral Health. JC: none known. I am a Co‐ordinating Editor of Cochrane Oral Health. DC: none known. MM: none known.

Figures

1
1
Study flow diagram.
2
2
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
3
3
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
1.1
1.1. Analysis
Comparison 1 Elective neck dissection (ND) versus therapeutic (delayed) neck dissection, Outcome 1 Total mortality (HR for overall survival).
1.2
1.2. Analysis
Comparison 1 Elective neck dissection (ND) versus therapeutic (delayed) neck dissection, Outcome 2 Total mortality.
1.3
1.3. Analysis
Comparison 1 Elective neck dissection (ND) versus therapeutic (delayed) neck dissection, Outcome 3 New disease, progression or mortality (HR for disease‐free survival).
1.4
1.4. Analysis
Comparison 1 Elective neck dissection (ND) versus therapeutic (delayed) neck dissection, Outcome 4 New disease, progression or mortality.
1.5
1.5. Analysis
Comparison 1 Elective neck dissection (ND) versus therapeutic (delayed) neck dissection, Outcome 5 Locoregional recurrence.
2.1
2.1. Analysis
Comparison 2 Radical neck dissection (ND) versus selective neck dissection, Outcome 1 Total mortality (HR for overall survival).
2.2
2.2. Analysis
Comparison 2 Radical neck dissection (ND) versus selective neck dissection, Outcome 2 New disease, progression or mortality (HR for disease‐free survival).
2.3
2.3. Analysis
Comparison 2 Radical neck dissection (ND) versus selective neck dissection, Outcome 3 Recurrence.
3.1
3.1. Analysis
Comparison 3 Surgery plus radiotherapy (RT) versus radiotherapy alone, Outcome 1 Total mortality (HR for overall survival).
4.1
4.1. Analysis
Comparison 4 Positron‐emission tomography‐computed tomography (PET‐CT) versus planned neck dissection, Outcome 1 Total mortality (HR for overall survival).
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References

References to studies included in this review

BHNCSG 1998 {published data only}
    1. Brazilian Head and Neck Cancer Study Group. Results of a prospective trial on elective modified radical classical versus supraomohyoid neck dissection in the management of oral squamous carcinoma. American Journal of Surgery 1998;176(5):422‐7. - PubMed
Bier 1994 {published data only}
    1. Bier J. Radical neck dissection versus conservative neck dissection for squamous cell carcinoma of the oral cavity. Recent Results in Cancer Research 1994;134:57‐62. - PubMed
    1. Bier J, Howaldt HP, Pitz H, 4th German‐Austrian‐Swiss Study Group therapy study. Prospective, randomized, clinical study of squamous cell cancer of the mouth: "Radical neck dissection versus conservative neck dissection". Fortschritte der Kiefer‐ und Gesichts‐Chirurgie 1992;37:108‐10. - PubMed
    1. Bier J, Schlums D, Metelmann H, Howaldt HP, Pitz H. A comparison of radical and conservative neck dissection. International Journal of Oral & Maxillofacial Surgery 1993;22(2):102‐7. - PubMed
D'Cruz 2015 {published data only}
    1. D'Cruz AK, Vaish R, Kapre N, Dandekar M, Gupta S, Hawaldar R, et al. Elective versus therapeutic neck dissection in node‐negative oral cancer. New England Journal of Medicine 2015;373(6):521‐9. [DOI: 10.1056/NEJMoa1506007] - DOI - PubMed
Fakih 1989 {published data only}
    1. Fakih AR, Rao RS, Borges AM, Patel AR. Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. American Journal of Surgery 1989;158(4):309‐13. - PubMed
    1. Fakih AR, Rao RS, Patel AR. Prophylactic neck dissection in squamous cell carcinoma of oral tongue: a prospective randomized study. Seminars in Surgical Oncology 1989;5(5):327‐30. - PubMed
Guo 2014 {published data only}
    1. Guo CB, Feng Z, Zhang JG, Peng X, Cai ZG, Mao C, et al. Supraomohyoid neck dissection and modified radical neck dissection for clinically node‐negative oral squamous cell carcinoma: a prospective study of prognosis, complications and quality of life. Journal of Craniofacial Surgery 2014;42(8):1885‐90. [DOI: 10.1016/j.jcms.2014.07.007] - DOI - PubMed
Iyer 2015 {published data only}
    1. Iyer NG, Tan DS, Tan VK, Wang W, Hwang J, Tan N‐C, et al. Randomized trial comparing surgery and adjuvant radiotherapy versus concurrent chemoradiotherapy in patients with advanced, nonmetastatic squamous cell carcinoma of the head and neck: 10‐year update and subset analysis. Cancer 2015;121(10):1599‐607. - PubMed
Kligerman 1994 {published data only}
    1. Kligerman J, Lima RA, Soares JR, Prado L, Dias FL, Freitas EQ, et al. Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of oral cavity. American Journal of Surgery 1994;168(5):391‐4. - PubMed
Mehanna 2017 {published data only}
    1. Mehanna H, McConkey CC, Rahman JK, Wong W‐L, Smith AF, Nutting C, et al. PET‐NECK a multicentre randomised phase III non‐inferiority trial comparing a positron emission tomography‐computerised tomography‐guided watch‐and‐wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer. Health Technology Assessment 2017; Vol. 21:17. [DOI: 10.3310/hta21170] - DOI - PMC - PubMed
    1. Mehanna H, Wong W‐L, McConkey CC, Rahman JK, Robinson M, Hartley AG, et al. PET‐CT surveillance versus neck dissection in advanced head and neck cancer. New England Journal of Medicine 2016;374(15):1444‐54. [DOI: 10.1056/NEJMoa1514493] - DOI - PubMed
Rastogi 2018 {published data only}
    1. Rastogi S, Sharma A, Choudhury R, Tripathi S, Al Wayli H, Amrithraj A, et al. Is superselective neck dissection safer than supraomohyoid neck dissection for oral carcinoma patients with N0 neck in terms of shoulder morbidity and recurrence rate?. Journal of Oral and Maxillofacial Surgery 2018;76(3):647‐55. [DOI: 10.1016/j.joms.2017.08.002] - DOI - PubMed
Robertson 1998 {published data only}
    1. Robertson AG, Soutar DS, Paul J, Webster M, Leonard AG, Moore KP, et al. Early closure of a randomized trial: surgery and postoperative radiotherapy versus radiotherapy in the management of intra‐oral tumours. Clinical Oncology (Royal College of Radiologists (Great Britain)) 1998;10(3):155‐60. - PubMed
Vandenbrouck 1980 {published data only}
    1. Vandenbrouck C, Sancho‐Garnier H, Chassagne D, Saravane D, Cachin Y, Micheau C. Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral cavity: results of a randomized clinical trial. Cancer 1980;46(2):386‐90. - PubMed
Yuen 2009 {published data only}
    1. Yuen AP, Ho CM, Chow TL, Tang LC, Cheung WY, Ng RW, et al. Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma. Head & Neck 2009;31(6):765‐72. - PubMed

References to studies excluded from this review

Abbade 2015 {published data only}
    1. Abbade L, Gige T, Amaral V, Aquino S, Miot H. Higher recurrence rates of head and neck nodular basal cell carcinoma treated with topical photodynamic therapy (MAL‐PDT) compared to surgical excision: a randomized controlled study. Journal of the American Academy of Dermatology 2015;72(5):AB185. [0190‐9622]
Ajmani 2017 {published data only}
    1. Ajmani GS, Nocon CC, Wang CH, Bhayani MK. Assessment of adjuvant therapy in resected head and neck cancer with high‐risk features. Oral Oncology 2017;74:15‐20. [DOI: 10.1016/j.oraloncology.2017.09.005] - DOI - PubMed
Ang 2001 {published and unpublished data}
    1. Ang KK, Trotti A, Brown BW, Garden AS, Foote RL, Morrison WH, et al. Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head‐and‐neck cancer. International Journal of Radiation Oncology, Biology, Physics 2001;51(3):571‐8. - PubMed
Batra 2016 {published data only}
    1. Batra J, Bekal RK, Byadgi S, Attresh G, Sambyal S, Vakade CD. Comparison of skin staples and standard sutures for closing incisions after head and neck cancer surgery: a double‐blind, randomized and prospective study. Journal of Maxillofacial and Oral Surgery 2016;15(2):243‐50. [DOI: 10.1007/s12663-015-0809-y] - DOI - PMC - PubMed
Bernier 2004 {published data only}
    1. Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefebvre JL, Greiner RH, et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. New England Journal of Medicine 2004;350(19):1945‐52. - PubMed
Bier 1981 {published data only}
    1. Bier J, Rapp HJ, Borsos T. Randomized clinical study on intratumoral BCG‐cell wall preparation (CWP) therapy in patients with squamous cell carcinoma in the head and neck region. Cancer Immunology, Immunotherapy 1981;12(1):71‐9.
Cooper 2004 {published data only}
    1. Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, et al. Postoperative concurrent radiotherapy and chemotherapy for high‐risk squamous‐cell carcinoma of the head and neck. New England Journal of Medicine 2004;350(19):1937‐44. - PubMed
Dean 2013 {published data only}
    1. Dean A, Alamillos F, Centella I, Garcia‐Alvarez S. Neck dissection with the harmonic scalpel in patients with squamous cell carcinoma of the oral cavity. Journal of Cranio‐maxillo‐facial Surgery 2013;42(1):84‐7. [DOI: 10.1016/j.jcms.2013.02.007] - DOI - PubMed
De Stefani 2002 {published data only}
    1. Stefani A, Forni G, Ragona R, Cavallo G, Bussi M, Usai A, et al. Improved survival with perilymphatic interleukin‐2 in patients with resectable squamous cell carcinoma of the oral cavity and oropharynx. Cancer 2002;95(1):90‐7. - PubMed
    1. Stefani A, Valente G, Forni G, Lerda W, Ragona R, Cortesina G. Treatment of oral cavity and oropharynx squamous cell carcinoma with perilymphatic interleukin‐2: clinical and pathologic correlations. Journal of Immunotherapy with Emphasis on Tumor Immunology 1996;19(2):125‐33. - PubMed
Fan 2017 {published data only}
    1. Fan S, Zhong JL, Chen WX, Chen WL, Li QX, Wang YY, et al. Postoperative immune response and surgical stress in selective neck dissection: comparison between endoscopically assisted dissection and open techniques in cT1‐2N0 oral squamous cell carcinoma. Journal of Cranio‐maxillo‐facial Surgery 2017;45(8):1112‐6. [DOI: 10.1016/j.jcms.2016.11.021] - DOI - PubMed
Fritz 2016 {published data only}
    1. Fritz DK, Matthews TW, Chandarana SP, Nakoneshny SC, Dort JC. Harmonic scalpel impact on blood loss and operating time in major head and neck surgery: a randomized clinical trial. Journal of Otolaryngology ‐ Head & Neck Surgery 2016;45(58):1‐6. [DOI: 10.1186/s40463-016-0173-z] - DOI - PMC - PubMed
Funahara 2017 {published data only}
    1. Funahara M, Yanamoto S, Ueda M, Suzuki T, Ota Y, Nishimaki F, et al. Prevention of surgical site infection after oral cancer surgery by topical tetracycline: results of a multicenter randomized controlled trial. Medicine 2017;96(48):1‐6. [DOI: ] - PMC - PubMed
George 2014 {published data only}
    1. George JR, Yom SS, Wang SJ. Improved outcomes in adjuvant radiotherapy for oral cavity carcinoma at an academic center: a matched‐pair analysis. Laryngoscope 2014;124(7):1603‐8. [DOI: 10.1002/lary.24552] - DOI - PubMed
Gundale 2017 {published data only}
    1. Gundale A, Rajdeep, Vasanthan L, Tirkey AK, Rajinikanth J. A randomised controlled trial of intraoperative brief electrical stimulation vs no stimulation of spinal accessory nerve for prevention of shoulder dysfunction after oncologic neck dissection in oral cavity squamous cell carcinomas‐an interim report. Head & Neck 2017; Vol. 39, issue S1:224.
Hintz 1979a {published data only}
    1. Hintz B, Charyulu K, Chandler JR, Sudarsanam A, Garciga C. Randomized study of local control and survival following radical surgery or radiation therapy in oral and laryngeal carcinomas. Journal of Surgical Oncology 1979;12(1):61‐74. - PubMed
Hintz 1979b {published data only}
    1. Hintz B, Charyulu K, Chandler JR, Sudarsanam A, Garciga C. Randomized study of control of the primary tumor and survival using preoperative radiation, radiation alone, or surgery alone in head and neck carcinomas. Journal of Surgical Oncology 1979;12(1):75‐85. - PubMed
Howard 2016 {published data only}
    1. Howard J, Masterson L, Dwivedi RC, Riffat F, Benson R, Jefferies S, et al. Minimally invasive surgery versus radiotherapy/chemoradiotherapy for small‐volume primary oropharyngeal carcinoma. Cochrane Database of Systematic Reviews 2016, Issue 12. [DOI: 10.1002/14651858.CD010963.pub2] - DOI - PMC - PubMed
Jinyun 2015 {published data only}
    1. Jinyun L, Wenxiao H, Jie C, Ronghua B. Clinical application of the combined radical operation without breaking lower lip and mandible for tongue and lingual root carcinoma. Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2015;50(3):225‐9. [10.3760/cma. j. issn. 1673‐0860. 2015. 03. 010; PUBMED: 26268496] - PubMed
Kramer 1987 {published data only}
    1. Kramer S, Gelber RD, Snow JB, Marcial VA, Lowry LD, Davis LW, et al. Combined radiation therapy and surgery in the management of advanced head and neck cancer: final report of study 73‐03 of the Radiation Therapy Oncology Group. Head & Neck Surgery 1987;10(1):19‐30. - PubMed
Lam 2001 {published data only}
    1. Lam P, Yuen AP, Ho CM, Ho WK, Wei WI. Prospective randomized study of post‐operative chemotherapy with levamisole and UFT for head and neck carcinoma. European Journal of Surgical Oncology 2001;27(8):750‐3. - PubMed
Laramore 1992 {published data only}
    1. Aref A, Berkey BA, Schwade JG, Ensley J, Schuller DE, Haselow RE, et al. The influence of beam energy on the outcome of postoperative radiotherapy in head and neck cancer patients: secondary analysis of RTOG 85‐03. International Journal of Radiation Oncology, Biology, Physics 2000;47(2):389‐94. - PubMed
    1. Jacobs JR, Casiano RR, Schuller DE, Pajak TF, Laramore GE, al‐Sarraf M. Chemotherapy as predictor of compliance. Journal of Surgical Oncology 1994;55(3):143‐8. - PubMed
    1. Laramore GE, Scott CB, al‐Sarraf M, Haselow RE, Ervin TJ, Wheeler R, et al. Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: report on Intergroup Study 0034. International Journal of Radiation Oncology, Biology, Physics 1992;23(4):705‐13. - PubMed
Lawrence 1974 {published data only}
    1. Lawrence W Jr, Terz JJ, Rogers C, King RE, Wolf JS, King ER. Proceedings: preoperative irradiation for head and neck cancer: a prospective study. Cancer 1974;33(2):318‐23. - PubMed
Licitra 2001 {published data only}
    1. Licitra L, Grandi C, Cavina R, Guzzo M, Mariani L, Lo Vullo S, et al. Primary chemotherapy (pCT) for patients with operable oral cavity cancer: results of a randomized study. Proceedings of the American Society of Clinical Oncology (ASCO) 2001;20:Abstract 890.
Lin 2016 {published data only}
    1. Lin WJ, Wang CC, Jiang RS, Huang YC, Ho HC, Liu SA. A prospective randomised trial of LigaSure Small Jaw® versus conventional neck dissection in head and neck cancer patients. Clinical Otolaryngology 2016;42(2):245‐51. - PubMed
Luboinski 1985 {published data only}
    1. Luboinski B. Preliminary results of a randomized study on preoperative intra‐arterial chemotherapy combined with surgery and irradiation for carcinomas of the floor of the mouth. Progress in Clinical and Biological Research 1985;201:199‐203. - PubMed
Maipang 1995 {published data only}
    1. Maipang T, Maipang M, Geater A, Panjapiyakul C, Watanaarepornchai S, Punperk S, et al. Combination chemotherapy as induction therapy for advanced resectable head and neck cancer. Journal of Surgical Oncology 1995;59(2):80‐5. - PubMed
McCaul 2012 {published data only}
    1. McCaul JA, Kulkami R, Gouldesbrough D, Boye T, Sutton D, Abdel‐Galil K, et al. LIHNCS; randomised control trial in oral and maxillofacial surgery interim data and recruitment report. British Journal of Oral & Maxillofacial Surgery 2012;50(1 Suppl):S22. [DOI: 10.1016/j.bjoms.2012.04.203] - DOI
McCaul 2017 {published data only}
    1. McCaul JA, McMahon JM, Quantrill J, Gilbert K, Mehanna HM, Shaw R, et al. LIHNCS: Lugol's iodine in head and neck cancer surgery – a multi‐centre, randomised, controlled trial assessing the effectiveness of Lugol's iodine to assist excision of moderate dysplasia, severe dysplasia and carcinoma in‐situ at mucosal resection margin of oral and oropharyngeal squamous cell carcinoma. Journal of Clinical Oncology 2017;35(15 Suppl):6065. [DOI: 10.1200/JCO.2017.35.15_suppl.6065] - DOI - PMC - PubMed
Minkovich 2011 {published data only}
    1. Minkovich L, Djaiani G, McCluskey SA, Mitsakakis N, Gilbert RW, Beattle WS. Frequent malpositions of peripherally inserted central venous catheters in patients undergoing head and neck surgery [Mauvais positionnements frequents des catheters veineux centraux inseres par voie peripherique chez les patients subissantune chirurgie au niveau de la tete et du cou]. Canadian Journal of Anesthesia 2011;58:709‐13. - PubMed
Mohr 1994 {published data only}
    1. Mohr C, Bohndorf W, Carstens J, Harle F, Hausamen JE, Hirche H, et al. Preoperative radiochemotherapy and radical surgery in comparison with radical surgery alone. A prospective, multicentric, randomized DOSAK study of advanced squamous cell carcinoma of the oral cavity and the oropharynx (a 3‐year follow‐up). International Journal of Oral and Maxillofacial Surgery 1994;23(3):140‐8. - PubMed
Neifeld 1985 {published data only}
    1. Neifeld JP, Terz JJ, Kaplan AM, Lawrence W Jr. Adjuvant corynebacterium parvum immunotherapy for squamous cell epitheliomas of the oral cavity, pharynx, and larynx. Journal of Surgical Oncology 1985;28(2):137‐45. - PubMed
Oswal 2017 {published data only}
    1. Oswal S, Borle R, Bhola N, Jadhav A, Surana S, Oswal R. Surgical staples: a superior alternative to sutures for skin closure after neck dissection – a single‐blinded prospective randomized clinical study. Journal of Oral and Maxillofacial Surgery 2017;75(12):2707.e1‐6. [DOI: 10.1016/j.joms.2017.08.004] - DOI - PubMed
Paccagnella 1994 {published data only}
    1. Paccagnella A, Orlando A, Marchiori C, Zorat PL, Cavaniglia G, Sileni VC, et al. Phase III trial of initial chemotherapy in stage III or IV head and neck cancers: a study by the Gruppo di Studio sui Tumori della Testa e del Collo. Journal of the National Cancer Institute 1994;86(4):265‐72. - PubMed
Poh 2011 {published data only}
    1. Poh CF, Durham JS, Brasher PM, Anderson DW, Berean KW, MacAulay CE, et al. Canadian Optically‐guided approach for Oral Lesions Surgical (COOLS) trial: study protocol for a randomized controlled trial. BMC Cancer 2011;11:462. [DOI: 10.1186/1471-2407-11-462] - DOI - PMC - PubMed
Rao 1991 {published data only}
    1. Rao RS, Parikh DM, Parikh HK, Bhansali MB, Deshmane VH, Fakih AR. Perioperative chemotherapy in patients with oral cancer. American Journal of Surgery 1994;168(3):262‐7. - PubMed
    1. Rao RS, Parikh DM, Parikh HK, Bhansali MB, Fakih AR. Perioperative chemotherapy in oral cancer. Journal of Surgical Oncology 1991;47(1):21‐6. - PubMed
Rentschler 1987 {published data only}
    1. Rentschler RE, Wilbur DW, Petti GH, Chonkich GD, Hilliard DA, Camacho ES, et al. Adjuvant methotrexate escalated to toxicity for resectable stage III and IV squamous head and neck carcinomas‐a prospective, randomized study. Journal of Clinical Oncology 1987;5(2):278‐85. - PubMed
Richard 1991 {published data only}
    1. Richard JM, Kramar A, Molinari R, Lefebvre JL, Blanchet F, Jortay A, et al. Randomised EORTC head and neck cooperative group trial of preoperative intra‐arterial chemotherapy in oral cavity and oropharynx carcinoma. European Journal of Cancer 1991;27(7):821‐7. - PubMed
Sanguineti 2005 {published and unpublished data}
    1. Sanguineti G, Richetti A, Bignardi M, Corvo R, Gabriele P, Sormani MP, et al. Accelerated versus conventional fractionated postoperative radiotherapy for advanced head and neck cancer: results of a multicenter phase III study. International Journal of Radiation Oncology, Biology, Physics 2005;61(3):762‐71. - PubMed
Schuller 1988 {published data only}
    1. Schuller DE, Metch B, Stein DW, Mattox D, McCracken JD. Preoperative chemotherapy in advanced resectable head and neck cancer: final report of the Southwest Oncology Group. Laryngoscope 1988;98(11):1205‐11. - PubMed
    1. Schuller DE, Stein DW, Metch B. Analysis of treatment failure patterns. A Southwest Oncology Group Study. Archives of Otolaryngology ‐ Head & Neck Surgery 1989;115(7):834‐6. - PubMed
Szabo 1999 {published data only}
    1. Szabo G, Kreidler J, Hollmann K, Kovacs A, Nemeth G, Nemeth Z, et al. Intra‐arterial preoperative cytostatic treatment versus preoperative irradiation: a prospective, randomized study of lingual and sublingual carcinomas. Cancer 1999;86(8):1381‐6. - PubMed
Szpirglas 1978 {published data only}
    1. Szpirglas H, Chastang C, Bertrand JC. Adjuvant treatment of tongue and floor of the mouth cancers. Recent Results in Cancer Research 1978;68:309‐17. - PubMed
Terz 1981 {published data only}
    1. Terz JJ, King ER, Lawrence W Jr. Preoperative irradiation for head and neck cancer: results of a prospective study. Surgery 1981;89(4):449‐53. - PubMed
Tingting 2016 {published data only}
    1. Tingting L, Canhua J, Jie C, Limeng W, Ruipu Z, Xinchun J. Application of carbon nanoparticles as lymph node tracers in patients with cN0 lingual squamous cell carcinoma undergoing neck dissection. West China Journal of Stomatology 2016;34(4):408‐13. [DOI: 10.7518/hxkq.2016.04.018] - DOI - PMC - PubMed
Uppal 2012 {published data only}
    1. Uppal A, Kakar FD, Uppal SA, Majeed R. Comparison of the complication between the radical neck dissection & selective neck dissection for the patient of oral squamous cell carcinoma. Medical Forum Monthly 2012;23(1):31‐4.
Verma 2017 {published data only}
    1. Verma RK, Mathiazhagan A, Panda NK. Neck dissection with harmonic scalpel and electrocautery? A randomised study. Auris Nasus Larynx 2017;44(5):590‐5. [DOI: 10.1016/j.anl.2016.11.004] - DOI - PubMed
Volling 1999 {published data only}
    1. Volling P, Schroder M. Preliminary results of a prospective randomized study of primary chemotherapy in carcinoma of the oral cavity and pharynx. HNO 1995;43(2):58‐64. - PubMed
    1. Volling P, Schroder M, Eckel H, Ebeling O, Stennert E. Results of a prospective randomized trial with induction chemotherapy for cancer of the oral cavity and tonsils. HNO 1999;47(10):899‐906. - PubMed
    1. Volling P, Schroder M, Muller RP, Ebeling O, Quirin R, Stennert E, et al. Induction chemotherapy in primary resectable head and neck tumors: a prospective randomized trial. International Journal of Oncology 1994;4(4):909‐14. - PubMed
Walen 2011 {published data only}
    1. Walen SG, Rudmik LR, Dixon E, Matthews TW, Nakoneshny SC, Dort JC. The utility of the harmonic scalpel in selective neck dissection: a prospective, randomized trial. Otolaryngology and Head and Neck Surgery 2011;144(6):894‐9. [DOI: 10.1177/0194599811403874] - DOI - PubMed
Weissler 1992 {published data only}
    1. Weissler MC, Melin S, Sailer SL, Qaqish F, Rosenman JG, Pillsbury HC. Simultaneous chemoradiation in the treatment of advanced head and neck cancer. Archives of Otolaryngology ‐ Head & Neck Surgery 1992;118(8):806‐10. - PubMed
Zhang 2010 {published data only}
    1. Zhang F, Yang K, Li Y, Chen DR, Xiang L. Comparison of surgical effects on patients with oral squamous cell carcinoma in cN0 stage operated in two kinds of neck dissection. Stomatology 2010; Vol. 30, issue 2:98‐100.
Zhong 2013 {published data only}
    1. Zhong LP, Zhang CP, Ren GX, Guo W, William WN Jr, Sun J, et al. Randomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up‐front surgery in locally advanced resectable oral squamous cell carcinoma. Journal of Clinical Oncology 2013;31(6):744‐51. [DOI: 10.1200/jco.2012.43.8820] - DOI - PMC - PubMed
Zhong 2015 {published data only}
    1. Zhong LP, Zhang CP, Ren GX, Guo W, William WN Jr, Hong CS, et al. Long‐term results of a randomized phase III trial of TPF induction chemotherapy followed by surgery and radiation in locally advanced oral squamous cell carcinoma. Oncotarget 2015;6(21):18707‐14. [DOI: 10.18632/oncotarget.4531] - DOI - PMC - PubMed

References to ongoing studies

NCT00571883 (SEND) {published data only}
    1. NCT00571883. The role of selective neck dissection used electively in patients with early oral squamous cell carcinoma (1‐3cm primary size) and no clinical evidence of lymph node metastases in the neck (SEND). clinicaltrials.gov/ct2/show/NCT00571883 Date first received 12 December 2007.
NCT01334320 {published data only}
    1. NCT01334320. Survival benefit of elective neck dissection in T1,2 N0 M0 oral squamous cell carcinoma. clinicaltrials.gov/ct2/show/NCT01334320 Date first received: 10 April 2015.
Nichols 2013 (formerly NCT01590355) {published data only}
    1. Nichols AC, Yoo J, Hammond AJ, Fung K, Winquist E, Read N, et al. Early‐stage squamous cell carcinoma of the oropharynx: radiotherapy vs. trans‐oral robotic surgery (ORATOR) – study protocol for a randomized phase II trial. BMC Cancer 2013;13(1):1‐9. [DOI: 10.1186/1471-2407-13-133] - DOI - PMC - PubMed

Additional references

Adelstein 2009
    1. Adelstein DJ, Ridge JA, Gillison ML, Chaturvedi AK, D'Souza G, Gravitt PE, et al. Head and neck squamous cell cancer and the human papillomavirus: summary of a National Cancer Institute State of the Science Meeting; 2008 Nov 9‐10; Washington (DC). Head & Neck 2009; Vol. 31, issue 11:1393‐422. - PubMed
Attner 2010
    1. Attner P, Du J, Nasman A, Hammarstedt L, Ramqvist T, Lindholm J, et al. The role of human papillomavirus in the increased incidence of base of tongue cancer. International Journal of Cancer 2010;126(12):2879‐84. - PubMed
Batsakis 1999
    1. Batsakis JG. Surgical excision margins: a pathologist's perspective. Advances in Anatomic Pathology 1999;6(3):140‐8. - PubMed
Blanchard 2011
    1. Blanchard P, Baujat B, Holostenco V, Bourredjem A, Baey C, Bourhis J, et al. Meta‐analysis of chemotherapy in head and neck cancer (MACH‐NC): a comprehensive analysis by tumour site. Radiotherapy Oncology 2011;100(1):33‐40. - PubMed
Brennan 2017
    1. Brennan PA, Bradley KL, Brands M. Intensity‐modulated radiotherapy in head and neck cancer – an update for oral and maxillofacial surgeons. British Journal of Oral and Maxillofacial Surgery 2017;55:770‐4. - PubMed
Brizel 1998
    1. Brizel DM, Albers ME, Fisher SR, Scher RL, Richtsmeier WJ, Hars V, et al. Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. New England Journal of Medicine 1998;338:1798‐804. - PubMed
Brizel 2011
    1. Brizel DM, Lydiatt W, Colevas AD. Controversies in the locoregional management of head and neck cancer. Journal of National Comprehensive Cancer Network 2011;9(6):653‐62. - PubMed
Carew 2003
    1. Carew JF, Singh B, Shah JP. Cervical lymph nodes. In: Shah JP, Johnson NW, Batsakis JG editor(s). Oral Cancer. London: Martin Dunitz, 2003:215‐49.
Chaturvedi 2008
    1. Chaturvedi AK, Engels EA, Anderson WF, Gillison ML. Incidence trends for human papillomavirus‐related and ‐unrelated oral squamous cell carcinomas in the United States. Journal of Clinical Oncology 2008;26:612‐9. - PubMed
Chaturvedi 2011
    1. Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. Journal of Clinical Oncology 2011;29:4294‐301. - PMC - PubMed
Chaturvedi 2013
    1. Chaturvedi AK, Anderson WF, Lortet‐Tieulent J, Curado MP, Ferlay J, Franceschi S, et al. Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers. Journal of Clinical Oncology 2013;31(36):4550‐9. - PMC - PubMed
Chaturvedi 2015
    1. Chaturvedi AK, Graubard BI, Broutian T, Pickard RK, Tong ZY, Xiao W, et al. NHANES 2009‐2012 findings: association of sexual behaviors with higher prevalence of oral oncogenic human papillomavirus infections in U.S. men. Cancer Research 2015;75:2468‐77. - PMC - PubMed
Conway 2008
    1. Conway DI, Petticrew M, Marlborough H, Berthiller J, Hashibe M, Macpherson LM. Socioeconomic inequalities and oral cancer risk: a systematic review and meta‐analysis of case‐control studies. International Journal of Cancer 2008;122(12):2811‐9. - PubMed
Conway 2015
    1. Conway DI, Brenner DR, McMahon AD, Macpherson LM, Agudo A, Ahrens W, et al. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case‐control studies from 27 countries. International Journal of Cancer 2015;136(5):1125‐39. - PMC - PubMed
D'Souza 2007
    1. D'Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, et al. Case‐control study of human papillomavirus and oropharyngeal cancer. New England Journal of Medicine 2007;356(19):1944‐56. - PubMed
Day 1992
    1. Day GL, Blot WJ. Second primary tumours in patients with oral cancer. Cancer 1992;70(1):14‐9. - PubMed
Deleyiannis 1997
    1. Deleyiannis FW, Weymuller EA, Coltrera MD. Quality of life of disease‐free survivors of advanced (stage III or IV) oropharyngeal cancer. Head and Neck 1997;19(6):466‐73. - PubMed
Dias 2001
    1. Dias FL, Kligerman J, Matos De Sa G, Arcuri RA, Freitas EQ, Farias T, et al. Elective neck dissection versus observation in stage I squamous carcinomas of the tongue and floor of the mouth. Otolaryngology, Head and Neck Surgery 2001;125:23‐9. - PubMed
Duprez 2017
    1. Duprez F, Berwouts D, Neve W, Bonte K, Boterberg T, Deron P, et al. Distant metastases in head and neck cancer. Head & Neck 2017;39(9):1733‐43. - PubMed
Ebrahimi 2012
    1. Ebrahimi A, Ashford BG, Clark JR. Improved survival with elective neck dissection in thick early‐stage oral squamous cell carcinoma. Head & Neck 2012;34(5):709‐16. - PubMed
Ewing 1952
    1. Ewing MR, Martin H. Disability following radical neck dissection. An assessment based on the postoperative evaluation of 100 patients. Cancer 1952;5:873‐83. - PubMed
Fakhry 2006
    1. Fakhry C, Gillison ML. Clinical implications of human papillomavirus in head and neck cancers. Journal of Clinical Oncology 2006;24(17):2606‐11. - PMC - PubMed
Fakhry 2008
    1. Fakhry C, Westra WH, Li S, Cmelak A, Ridge JA, Pinto H, et al. Improved survival of patients human papillomavirus – positive head and neck squamous cell carcinoma in a prospective clinical trial. Journal of the National Cancer Institute 2008;100(4):261‐9. - PubMed
Fasunla 2011
    1. Fasunla AJ, Greene BH, Timmesfeld N, Wiegand S, Werner JA, Sesterhenn AM. A meta‐analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node‐negative neck. Oral Oncology 2011;47(5):320‐4. - PubMed
Ferlay 2013
    1. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. Cancer incidence and mortality worldwide: IARC CancerBase. International Agency for Research on Cancer GLOBOCAN 2012 v1.0 2013; Vol. 11.
Freedman 2007
    1. Freedman ND, Abnet CC, Leitzmann MF, Hollenbeck AR, Schatzkin A. Prospective investigation of the cigarette smoking‐head and neck cancer association by sex. Cancer 2007;110(7):1593‐601. - PubMed
Furness 2011
    1. Furness S, Glenny AM, Worthington HV, Pavitt S, Oliver R, Clarkson JE, et al. Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy. Cochrane Database of Systematic Reviews 2011, Issue 4. [DOI: 10.1002/14651858.CD006386.pub3] - DOI - PubMed
Gillison 2000
    1. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. Journal of National Cancer Institute 2000;92:709‐20. - PubMed
Gillison 2007
    1. Gillison ML. Current topics in the epidemiology of oral cavity and oropharyngeal cancers. Head & Neck 2007;29:779‐92. - PubMed
Glenny 2010
    1. Glenny AM, Furness S, Worthington HV, Conway DI, Oliver R, Clarkson JE, et al. Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy. Cochrane Database of Systematic Reviews 2010, Issue 12. [DOI: 10.1002/14651858.CD006387.pub2] - DOI - PMC - PubMed
Gupta 2014
    1. Gupta B, Johnson NW. Systematic review and meta‐analysis of association of smokeless tobacco and of betel quid without tobacco with incidence of oral cancer in South Asia and the Pacific. PloS One 2014;9(11):e113385. - PMC - PubMed
Haddadin 2000
    1. Haddadin KJ, Soutar DS, Webster MH, Robertson AG, Oliver RJ, MacDonald DG. Natural history and patterns of recurrence of tongue tumours. British Journal of Plastic Surgery 2000;53(4):279‐85. - PubMed
Higgins 2011
    1. Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
Holden 2018
    1. Holden AM, Sharma D, Schilling C, Gnanasegaran G, Odell EW, Sassoon I, et al. Biopsy of the sentinel lymph node in oral squamous cell carcinoma: analysis of error in 100 consecutive cases. British Journal of Oral and Maxillofacial Surgery 2018;56(7):615‐20. [DOI: 10.1016/j.bjoms.2018.06.019] - DOI - PubMed
Holsinger 2015
    1. Holsinger FC, Ferris RL. Transoral endoscopic head and neck surgery and its role within the multidisciplinary treatment paradigm of oropharynx cancer: robotics, lasers and clinical trials. Journal of Clinical Oncology 2015;33(29):3285‐92. - PMC - PubMed
Hughes 1993
    1. Hughes CJ, Gallo O, Spiro RH, Shah JP. Management of occult neck metastases in oral cavity squamous carcinoma. American Journal of Surgery 1993;166(4):380‐3. - PubMed
Hughes 2012
    1. Hughes C, Homer J, Bradley P, Nutting C, Ness A, Persson M, et al. An evaluation of current services available for people diagnosed with head and neck cancer in the UK (2009‐2010). Clinical Oncology 2012;24(10):187‐9. - PubMed
Kowalski 2007
    1. Kowalski LP, Sanabria A. Elective neck dissection in oral carcinoma: a critical review of the evidence. Acta Otorhinolaryngologica Italica 2007;27(3):113‐7. - PMC - PubMed
La Vecchia 1997
    1. Vecchia C, Tavani A, Franceschi S, Levi F, Corrao G, Negri E. Epidemiology and prevention of oral cancer. Oral Oncology 1997;33(5):302‐12. - PubMed
Lefebvre 2011
    1. Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
Licitra 2006
    1. Licitra L, Perrone F, Bossi P, Suardi S, Mariani L, Artusi R, et al. High‐risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma. Journal of Clinical Oncology 2006;24(36):5630‐6. - PubMed
Lo Nigro 2017
    1. Lo Nigro C, Denaro N, Merlotti A, Merlano M. Head and neck cancer: improving outcomes with a multidisciplinary approach. Cancer Management and Research 2017;18(9):363‐71. - PMC - PubMed
Louie 2015
    1. Louie KS, Mehanna H, Sasieni P. Trends in head and neck cancers in England from 1995 to 2011 and projections up to 2025. Oral Oncology 2015;51(4):341‐8. - PubMed
Macfarlane 1995
    1. Macfarlane GJ, Zheng T, Marshall JR, Boffetta P, Niu S, Brasure J, et al. Alcohol, tobacco, diet and the risk of oral cancer: a pooled analysis of three case‐control studies. European Journal of Cancer. Part B, Oral Oncology 1995;31B(3):181‐7. - PubMed
McGurk 2005
    1. McGurk M, Vhan C, Jones J, O'Regan E, Sherriff M. Delay in diagnosis and its effect on outcome in head and neck cancer. British Journal of Oral and Maxillofacial Surgery 2005;43(4):281‐4. - PubMed
NICE 2018
    1. National Institute for Health and Care Excellence. Cancer of the upper aerodigestive tract: assessment and management in people aged 16 and over. www.nice.org.uk/guidance/ng36 (accessed prior to 6 December 2018). [www.nice.org.uk/guidance/ng36] - PubMed
Paleri 2016
    1. Paleri V, Urbano TG, Mehanna H, Repanos C, Lancaster J, Roques T, et al. Management of neck metastases in head and neck cancer: United Kingdom National Multidisciplinary Guidelines. Journal of Laryngology and Otology 2016;130(Suppl S2):S161‐9. [DOI: 10.1017/S002221511600058X] - DOI - PMC - PubMed
Parkin 2005
    1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA: a Cancer Journal for Clinicians 2005;55(2):74‐108. - PubMed
Parmar 1998
    1. Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta‐analysis of the published literature for survival endpoints. Statistics in Medicine 1998;17(24):2815‐34. - PubMed
Parsons 2002
    1. Parsons JT, Mendenhall WM, Stringer SP, Amdur RJ, Hinerman RW, Villaret DB, et al. Squamous cell carcinoma of the oropharynx: surgery, radiation therapy, or both. Cancer 2002;94(11):2967‐80. - PubMed
Partridge 2000
    1. Partridge M, Li SR, Pateromichelakis S, Francis R, Phillips E, Huang XH, et al. Detection of minimal residual cancer to investigate why oral tumors recur despite seemingly adequate treatment. Clinical Cancer Research 2000;6(7):2718‐25. - PubMed
Purkayastha 2016
    1. Purkayastha M, McMahon AD, Gibson J, Conway DI. Trends of oral cavity, oropharyngeal and laryngeal cancer incidence in Scotland (1975‐2012) – a socioeconomic perspective. Oral Oncology 2016;61:70‐5. - PubMed
Robbins 2002
    1. Robbins KT, Clayman G, Levine PA, Medina J, Sessions R, Shaha A, et al. Neck dissection classification update: revisions proposed by the American Head and Neck Society and the American Academy of Otolaryngology‐Head and Neck Surgery. Archives of Otolaryngology ‐ Head & Neck Surgery 2002;128(7):751‐8. - PubMed
Ryerson 2008
    1. Ryerson AB, Peters EB, Coughlin SS, Chen VW, Gillison ML, Reichman ME, et al. Burden of potentially human papillomavirus‐associated cancers of the oropharynx and oral cavity in the US. Cancer 2008;113(10 Suppl):2901‐9. - PubMed
Schilling 2015
    1. Schilling C, Stoeckli SJ, Haerle SK, Broglie MA, Huber GF, Sorensen JA, et al. Sentinel European Node Trial (SENT): 3‐year results of sentinel node biopsy in oral cancer. European Journal of Cancer 2015;51:2777‐84. - PubMed
Schilling 2017
    1. Schilling C, Shaw R, Schache A, McMahon J, Chegini S, Kerawala C, et al. Sentinel lymph node biopsy for oral squamous cell carcinoma. Where are we now?. British Journal of Oral and Maxillofacial Surgery 2017;55:757‐62. - PubMed
Shah 1990
    1. Shah JP. Cervical lymph node metastases – diagnostic, therapeutic, and prognostic implications. Oncology (Williston Park, N.Y.) 1990;4(10):61‐9. - PubMed
Simard 2014
    1. Simard EP, Torre LA, Jemal A. International trends in head and neck cancer incidence rates: differences by country, sex and anatomic site. Oral Oncology 2014;50(5):387‐403. - PubMed
Stewart 2014
    1. Stewart B, Wild CP, editor(s). World cancer report. International Agency for Research on Cancer, WHO 2014.
Studer 2007
    1. Studer G, Zwahlen RA, Graetz KW, Davis BJ, Glanzmann C. IMRT in oral cavity cancer. Radiation Oncology 2007;2(16):1‐7. - PMC - PubMed
Sturgis 2007
    1. Sturgis EM, Cinciripini PM. Trends in head and neck cancer incidence in relation to smoking prevalence. Cancer 2007;110(7):1429‐35. - PubMed
Sutton 2003
    1. Sutton DN, Brown JS, Rogers SN, Vaughan ED, Woolgar JA. The prognostic implications of the surgical margin in oral squamous cell carcinoma. International Journal of Oral and Maxillofacial Surgery 2003;32(1):30‐4. - PubMed
Tapia 2011
    1. Tapia JL, Goldberg LJ. The challenges of defining oral cancer: analysis of an ontological approach. Head and Neck Pathology 2011;5:376‐84. - PMC - PubMed
Torre 2015
    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet‐Tieulent J, Jemal A. Global cancer statistics, 2012. CA: a Cancer Journal for Clinicians 2015;65(2):87‐108. - PubMed
Umeda 2010
    1. Umeda M, Shigeta T, Takahashi H, Oguni A, Katakoa T, Minamikawa T, et al. Shoulder mobility after spinal accessory nerve‐sparing modified radical neck dissection in oral cancer patients. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 2010;109:820‐4. - PubMed
Warnakulasuriya 2009
    1. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncology 2009;45(4‐5):309‐16. - PubMed
WHO 1990
    1. World Health Organization. International Classification of Diseases for Oncology (ICD‐O). 2nd Edition. Geneva: World Health Organization, 1990.
Winn 2015
    1. Winn DM, Lee YC, Hashibe M, Boffetta P. The INHANCE consortium: toward a better understanding of the causes and mechanisms of head and neck cancer. Oral Diseases 2015;21(6):685‐93. - PubMed
Woolgar 2003
    1. Woolgar JA, Rogers SN, Lowe D, Brown JS, Vaughan ED. Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread. Oral Oncology 2003;39(2):130‐7. - PubMed
Worthington 2015
    1. Worthington H, Clarkson J, Weldon J. Priority oral health research identification for clinical decision‐making. Evidence‐based Dentistry 2015;16(3):69‐71. - PubMed
Yang 2017
    1. Yang Y, Zhoug J, Wu H. Diagnostic value of sentinel node biopsy for cT1/T2N0 tongue squamous cell carcinoma: a meta‐analysis. European Archives of Oto‐rhino‐laryngology 2017;274:3843‐52. - PubMed

References to other published versions of this review

Bessell 2011
    1. Bessell A, Glenny AM, Furness S, Clarkson JE, Oliver R, Conway DI, et al. Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment. Cochrane Database of Systematic Reviews 2011, Issue 9. [DOI: 10.1002/14651858.CD006205.pub3] - DOI - PubMed
Oliver 2007
    1. Oliver R, Clarkson JE, Conway D, Glenny AM, Macluskey M, Pavitt S, et al. Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment. Cochrane Database of Systematic Reviews 2007, Issue 4. [DOI: 10.1002/14651858.CD006205.pub2] - DOI - PubMed

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