Marked Increases in Resting-State MEG Gamma-Band Activity in Combat-Related Mild Traumatic Brain Injury

doi:10.1093/cercor/bhz087

. 2020 Jan 10;30(1):283-295.

doi: 10.1093/cercor/bhz087.

Marked Increases in Resting-State MEG Gamma-Band Activity in Combat-Related Mild Traumatic Brain Injury

Ming-Xiong Huang^{1

2}, Charles W Huang³, Deborah L Harrington^{1

2}, Sharon Nichols⁴, Ashley Robb-Swan^{1

2}, Annemarie Angeles-Quinto^{1

2}, Lu Le⁵, Carl Rimmele⁵, Angela Drake⁶, Tao Song², Jeffrey W Huang⁷, Royce Clifford^{1

8

9}, Zhengwei Ji², Chung-Kuan Cheng¹⁰, Imanuel Lerman¹, Kate A Yurgil^{1

9

11}, Roland R Lee^{1

2}, Dewleen G Baker^{1

8

9}

Affiliations

¹ Radiology, Research, and Psychiatry Services, VA San Diego Healthcare System, San Diego, CA, USA.
² Department of Radiology, University of California, San Diego, CA, USA.
³ Department of Bioengineering, Stanford University, Stanford, CA, USA.
⁴ Department of Neuroscience, University of California, San Diego, CA, USA.
⁵ ASPIRE Center, VASDHS Residential Rehabilitation Treatment Program, San Diego, CA, USA.
⁶ Cedar Sinai Medical Group Chronic Pain Program, Beverly Hills, CA, USA.
⁷ Department of Computer Science, Columbia University, New York, NY, USA.
⁸ Department of Psychiatry, University of California, San Diego, CA, USA.
⁹ VA Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
¹⁰ Department of Computer Science and Engineering, University of California, San Diego, CA, USA.
¹¹ Department of Psychological Sciences, Loyola University, New Orleans, LA, USA.

PMID: 31041986
DOI: 10.1093/cercor/bhz087

Free article

Marked Increases in Resting-State MEG Gamma-Band Activity in Combat-Related Mild Traumatic Brain Injury

Ming-Xiong Huang et al. Cereb Cortex. 2020.

Free article

. 2020 Jan 10;30(1):283-295.

doi: 10.1093/cercor/bhz087.

Authors

Affiliations

¹ Radiology, Research, and Psychiatry Services, VA San Diego Healthcare System, San Diego, CA, USA.
² Department of Radiology, University of California, San Diego, CA, USA.
³ Department of Bioengineering, Stanford University, Stanford, CA, USA.
⁴ Department of Neuroscience, University of California, San Diego, CA, USA.
⁵ ASPIRE Center, VASDHS Residential Rehabilitation Treatment Program, San Diego, CA, USA.
⁶ Cedar Sinai Medical Group Chronic Pain Program, Beverly Hills, CA, USA.
⁷ Department of Computer Science, Columbia University, New York, NY, USA.
⁸ Department of Psychiatry, University of California, San Diego, CA, USA.
⁹ VA Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
¹⁰ Department of Computer Science and Engineering, University of California, San Diego, CA, USA.
¹¹ Department of Psychological Sciences, Loyola University, New Orleans, LA, USA.

PMID: 31041986
DOI: 10.1093/cercor/bhz087

Abstract

Combat-related mild traumatic brain injury (mTBI) is a leading cause of sustained impairments in military service members and veterans. Recent animal studies show that GABA-ergic parvalbumin-positive interneurons are susceptible to brain injury, with damage causing abnormal increases in spontaneous gamma-band (30-80 Hz) activity. We investigated spontaneous gamma activity in individuals with mTBI using high-resolution resting-state magnetoencephalography source imaging. Participants included 25 symptomatic individuals with chronic combat-related blast mTBI and 35 healthy controls with similar combat experiences. Compared with controls, gamma activity was markedly elevated in mTBI participants throughout frontal, parietal, temporal, and occipital cortices, whereas gamma activity was reduced in ventromedial prefrontal cortex. Across groups, greater gamma activity correlated with poorer performances on tests of executive functioning and visuospatial processing. Many neurocognitive associations, however, were partly driven by the higher incidence of mTBI participants with both higher gamma activity and poorer cognition, suggesting that expansive upregulation of gamma has negative repercussions for cognition particularly in mTBI. This is the first human study to demonstrate abnormal resting-state gamma activity in mTBI. These novel findings suggest the possibility that abnormal gamma activities may be a proxy for GABA-ergic interneuron dysfunction and a promising neuroimaging marker of insidious mild head injuries.

Keywords: cognition; frontoparietal network; gamma activity; magnetoencephalography; mild traumatic brain injury.

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Marked Increases in Resting-State MEG Gamma-Band Activity in Combat-Related Mild Traumatic Brain Injury

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Marked Increases in Resting-State MEG Gamma-Band Activity in Combat-Related Mild Traumatic Brain Injury

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