Bone Remodeling in Osteoarthritis-Biological and Radiological Aspects
- PMID: 37763732
- PMCID: PMC10537088
- DOI: 10.3390/medicina59091613
Bone Remodeling in Osteoarthritis-Biological and Radiological Aspects
Abstract
Among available papers published on the given subject over the last century, various terms have been used as synonyms for one, now generally accepted-osteoarthritis, in some countries called "wear and tear" or "overload arthritis". The opsolent terms-hypertrophic arthritis, degenerative arthritis, arthritis deformans and osteoarthrosis-sought to highlight the dominant clinical signs of this ubiquitous, polymorph disease of the whole osteochondral unit, which by incidence and prevalence represents one of the leading chronic conditions that cause long-term pain and incapacity for work. Numerous in vitro and in vivo research resulted in broadened acknowledgments about osteoarthritis pathophysiology and pathology on both histological and cellular levels. However, the cause of osteoarthritis is still unknown and is currently the subject of a hypothesis. In this paper, we provide a review of recent findings on biological phenomena taking place in bone tissue during osteoarthritis to the extent useful for clinical practice. Choosing a proper radiological approach is a conditio sine qua non to the early diagnosis of this entity.
Keywords: bone remodeling; osteoarthritis; osteophyte.
Conflict of interest statement
The authors declare no conflict of interest.
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References
-
- Đudarić L. Ph.D. Thesis. Medicinski Fakultet Sveučilišta u Rijeci; Rijeka, Croatia: 2014. Izražaj Osteoniduktivnih Proteina I Njihovih Inhibitora Tijekom Osteogeneze.
-
- Lian J.B., Stein G.S. Osteoblast Biology. In: Marcus R., Feldman D., Kelsey J., editors. Osteoporosis. Academic Press Inc.; San Diego, CA, USA: 1996. pp. 23–35.
-
- Đudarić L., Zoričić Cvek S., Cvijanović O., Fužinac-Smojver A., Ćelić T., Martinović D. Osnove biologije koštanog tkiva. Med. Flum. 2014;50:21–38.
-
- Zoričić Cvek S., Bobinac D., Đudarić L., Cvijanović O. Pregradnja koštanog sustava. Med. Flum. 2015;51:482–493.
-
- Becker K.L. Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins; Philadelphia, PA, USA: 2001.
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