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Ligand Pharmaceuticals

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Ligand Pharmaceuticals Incorporated
Company typePublic
IndustryBiopharmaceuticals
FoundedSeptember 1987; 37 years ago (1987-09)
FounderBrook Byers[1]
HeadquartersJupiter, Florida, U.S.
Key people
Todd C. Davis (CEO)
RevenueUS$167.13 million (FY24)[2]
Number of employees
68 (2024)
Websiteligand.com

Ligand Pharmaceuticals Incorporated is a biopharmaceutical company located in Jupiter, Florida.[3] Founded in 1987 as Progenix Inc., the company went public in 1992. Initially focused on developing its own drugs, a period of turbulence in the early 2000s culminated in its CEO being ejected by the shareholders and provoked a change in focus to the acquisition of existing drugs and forming partnerships to develop them further.[citation needed]

The company has been the subject of multiple regulatory investigations,[4] negative shorts-seller reports[5] and class action lawsuits amid allegations of securities fraud.[6][7][8][9]

In 2018 its CEO was listed among the top five highest paid CEOs in San Diego.[10]

History

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Ligand Pharmaceuticals was founded, as Progenix Inc., in 1987 by Brook Byers and went public in late 1992.[11] Its first CEO was Howard Birndorf, succeeded by David Robinson, both of whom focused on developing drugs based on orphan nuclear receptors.[4]

In September 2005, the company was delisted by the NASDAQ following "accounting irregularities," that resulted in late filings.[12] The same month the Securities and Exchange Commission of the company's financial reporting, which was characterized as "questionable," and resulted in a "lengthy scandal" according to The San Diego Union-Tribune.[13][14] In October 2005, the company as well as the Board of Directors and certain officers were named as defendants in a shareholder derivative lawsuit alleging breach of fiduciary duty[7] and that Ligand artificially inflated its revenue by engaging in “channel stuffing.”[6] In June 2006, Ligand agreed to pay $12.2 million to settle a securities class-action lawsuit as well as related state and federal shareholder derivative lawsuits that alleged the company had engaged in accounting improprieties.[6]

In addition to accounting irregularities, by 2006 the company had reported no profits despite some of the drugs the company developed being approved, and dissident shareholders, including Dan Loeb, forced Robinson out.[citation needed] He was replaced as CEO by Henry F. Blissenbach who sold all the company's commercial operations and cut the workforce.[citation needed] In January 2007 John Higgins, a former investment banker, was brought in as CEO. He changed the company's strategy to one of acquiring candidate drugs and forming partnerships to develop them further.[4]

In the late 2000s, the company used its capital to acquire other companies including Neurogen, Pharmacopeia biotechnology, Metabasis Therapeutics and Cydex Pharmaceuticals. CEO Higgins stated that the result of the purchases was a portfolio of some 60 new drug candidates, partnerships with pharmaceutical companies and other assets.[4]

In November 2016, The Shareholder Foundation filed a class action lawsuit against Ligand, alleging the company had engaged in securities fraud by making false and misleading statements, overstating the value of its assets, mis-classifying its debt, and by failing to maintain control over its accounting.[8] A separate class-action lawsuit, filed the same month, which named Ligand CEO John Higgins and CFO Matthew Korenberg, alleged, the company's "wrongful acts and omissions" led to a "precipitous" decline the market value of the company's stock and that the company's investors had suffered "significant losses and damages."[15]

In December 2016, Ligand was named as a defendant in multiple securities class action lawsuits, alleging the company had engaged in securities fraud by making false or misleading statements about its financial condition and its ability to control its reporting.[16][17]

In July 2018, Ligand was sued by investors, including Citadel, for $3.8 billion, alleging the company unfairly modified its agreements with investors and never filed the amendment with the U.S. Securities and Exchange Commission.[9]

Business

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Ligand Pharmaceuticals' business is the acquisition of royalty rights to commercially available and in-development pharmaceutical products.[18][19] In 2024, the company's portfolio contained approximately 90 therapies and drugs.[19]

Ligand is entitled to royalties on the following products:

Short Seller

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In June 2014, Emmanuel Lemelson, while shorting Ligand stock, published 56 pages of reports that criticized the company as a fraud and alleged the company was insolvent.[5] The commentary caused a $500 million drop in the company's market capitalization and a profit of $1.4 million to Lemelson. Ligand executives, former high ranking-SEC lawyer Brad Bondi and congressmen Duncan Hunter subsequently lobbied the U.S. Securities and Exchange Commission to charge Lemelson.[34][35] According to company emails and trial testimony, Ligand CEO John Higgins wanted Lemelson "silenced for good."[34][36] In September 2018, the SEC sued Lemelson for an alleged "manipulative scheme" to defraud investors. On November 5, 2021, a federal jury rejected the allegations in a mixed verdict,[37] which cleared Lemelson of the commentary on Ligand in his reports but did find misstatements, including about a different company, Viking Therapeutics.[38][39] Lemelson was subsequently fined $160,000.[40]

References

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  1. ^ "Ligand Pharmaceuticals Incorporated History". Funding Universe.
  2. ^ "Form 10-K" (PDF). U.S. Securities and Exchange Commission. February 25, 2025. Retrieved March 17, 2025.
  3. ^ "Form 10-K" (PDF). U.S. Securities and Exchange Commission. February 25, 2025. Retrieved March 17, 2025.
  4. ^ a b c d Bigelow, Bruce (March 25, 2011). "San Diego's Ligand Takes Advantage of the Great Recession to Build New Drug Pipeline". Xconomy. Retrieved 13 September 2018.
  5. ^ a b "Priest Urged Investors To 'Run' From Pharma Biz, Jury Hears - Law360". www.law360.com. Retrieved 2022-10-01.
  6. ^ a b c "Ligand to pay $12.2 million to settle lawsuits". The San Diego Union-Tribune. Retrieved 2018-09-12.
  7. ^ a b "Ligand Announces Recently Filed Shareholder Derivative Lawsuit". Retrieved 2018-09-12.
  8. ^ a b "Lawsuit for Investors in Ligand Pharmaceuticals Inc. (NASDAQ:LGND) over alleged Violations of Securities Laws announced by Shareholders Foundation". GlobeNewswire News Room. Retrieved 2018-09-12.
  9. ^ a b "Ligand Pharmaceuticals Sued for $3.8 Billion Over Bond Terms". Retrieved 2018-09-12.
  10. ^ "How the 16 highest-paid CEOs of San Diego public companies made their money". San Diego Union-Tribune. 2019-07-14. Retrieved 2022-10-01.
  11. ^ "Ligand Pharmaceuticals Incorporated". Company Histories. 2002. Retrieved 16 September 2018.
  12. ^ "Ligand loses its listing on Nasdaq". The San Diego Union-Tribune. Retrieved 2018-09-12.
  13. ^ "Ligand Announces SEC Investigation". www.shareholder.com. September 12, 2005.
  14. ^ "SEC starts probe into Ligand's accounting". The San Diego Union-Tribune. Retrieved 2018-09-12.
  15. ^ "Investors Sue Ligand Over Exaggerated Financials". 2016-11-19. Retrieved 2018-09-12.
  16. ^ "Ligand Pharmaceuticals facing securities class action". Battea Class Action Services. 2016-12-28. Retrieved 2018-09-12.
  17. ^ "Ligand Pharmaceuticals Inc. Investigated For Securities Fraud By Block & Leviton After Announcing Restatement Of Financial Results". www.prnewswire.com (Press release). Retrieved 2018-09-12.
  18. ^ Fisher, Daniel (July 1, 2015). "Life After Loeb: Ligand Pharmaceuticals Prospers In Stripped-Down Mode". Forbes. Retrieved April 15, 2025.
  19. ^ a b Moran, Nuala (July 10, 2024). "Apeiron exits through M&A as Ligand gains Qarziba royalties". BioWorld. Retrieved April 8, 2025.
  20. ^ Liu, Angus (February 17, 2023). "With FDA approval for Filspari, Travere turns Bristol Myers castoff into unique drug for rare kidney disease". Fierce Pharma. Retrieved February 22, 2025.
  21. ^ Taylor, Phil (July 9, 2024). "Ligand grows in cancer again with $100m Apeiron takeover". Pharma Phorum. Retrieved February 22, 2025.
  22. ^ Sternberg, Charlie (June 18, 2024). "Merck Receives FDA Approval for CAPVAXIVE". Contract Pharma. Retrieved April 4, 2025.
  23. ^ "Ligand Pharmaceuticals to acquire APEIRON Biologics for $100m". Pharmaceutical Technology. July 9, 2024. Retrieved February 22, 2025.
  24. ^ Dunleavy, Kevin (January 2, 2025). "2024 drug approvals: Small companies loom large with several key FDA nods". Fierce Pharma. Retrieved February 22, 2025.
  25. ^ Broderick, Jason M. (March 15, 2016). "FDA Approves New Melphalan Formulation in Myeloma". OncLive. Retrieved February 22, 2025.
  26. ^ Vielma, Antonio José (September 27, 2016). "Shares of Ligand plunge 12% after Amgen drug misses study goal". CNBC. Retrieved February 22, 2025.
  27. ^ Myshko, Denise (July 21, 2021). "Jazz Pharmaceuticals Launches ALL Therapy Rylaze". Managed Healthcare Executive. Retrieved April 7, 2025.
  28. ^ Terry, Mark (August 11, 2020). "Ligand Buys Pfenex in $516 Million Deal to Access Protein Production Platform". BioSpace. Retrieved February 22, 2025.
  29. ^ Terry, Mark (July 16, 2021). "FDA Action Alert: Merck, Ligand and Albireo Pharma". BioSpace. Retrieved February 22, 2025.
  30. ^ "Ligand Acquires Royalty on Sanofi's TZIELD® for $20M". American Pharmaceutical Review. November 1, 2023. Retrieved February 22, 2025.
  31. ^ "Gavi-supported pneumococcal conjugate vaccines profiles to support country decision making" (PDF). GAVI. 2019. Archived (PDF) from the original on 19 May 2020. Retrieved 8 April 2020.
  32. ^ "Ligand (LGND) Completes Acquisition of Pfenex Inc. (PFNX)". StreetsInsider. October 1, 2020. Retrieved April 8, 2025.
  33. ^ Sirk, Kimberly (May 30, 2011). "What's Next(erone) for Baxter". Drug Discovery News. Retrieved April 7, 2025.
  34. ^ a b Alpert, Bill. "Hedge Fund Alleges SEC Bias in Short-Selling Case". www.barrons.com. Retrieved 2022-10-01.
  35. ^ "Priest Points Finger At Biotech As SEC Short Sale Trial Wraps - Law360". www.law360.com. Retrieved 2022-10-01.
  36. ^ "Priest Points Finger At Biotech As SEC Short Sale Trial Wraps - Law360". www.law360.com. Retrieved 2023-01-14.
  37. ^ "Jury Clears Priest in 'Short-and-Distort' Scheme". CFO. 2021-11-08. Retrieved 2022-10-01.
  38. ^ "Hedge Fund Priest Beats SEC Short-And-Distort Claims - Law360". www.law360.com. Retrieved 2022-10-01.
  39. ^ Alpert, Bill. "The SEC Wins Mixed Verdict Against a Short Seller Who Wouldn't Settle". www.barrons.com. Retrieved 2022-10-01.
  40. ^ "Hedge Fund Priest Seeks Total Victory Over SEC Stock Suit - Law360". www.law360.com. Retrieved 2022-10-01.
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