Abstract: A method and associated computer system. A first machine executes machine code in a debugging session on the first machine. The machine code had been previously received by the first machine from a second machine. The machine code includes machine executable instructions. The machine code was generated from compilation of source code developed and compiled on the second machine. In response to a change in the machine code having detected by the first machine in the debugging session on the first machine, the first machine determines a portion of the source code associated with the change in the machine code based on a profile. The profile indicates a mapping between the source code and the machine code. The first machine, while communicating with the second machine, causes the portion of the source code to be updated on the second machine based on the change in the machine code.

Abstract: Provided are a compound for treating metabolic diseases having the structure as shown in formula (I) or formula (II), or a racemate, stereoisomer, geometric isomer, tautomer, solvate, hydrate, metabolite, pharmaceutically acceptable salt or prodrug thereof. The compound is an activator of FXR and/or a TGR5 receptor, and thus has the activity of activating FXR and/or a TGR5 receptor, and can be used in the preparation of drugs for treating chronic liver diseases, metabolic diseases or portal hypertension.

Abstract: A fusion protein having a non-immunoglobulin polypeptide having a cysteine residue proximal to the C terminal thereof, and an immunoglobulin component with a mutated hinge region is provided. The mutation comprises a point mutated site corresponding in position to the position in a native hinge region of the cysteine residue located nearest the cysteine residue of the non-Ig component. The distance from the cysteine residue of the non-immunoglobulin polypeptide and any remaining cysteine residues of the mutated hinge region is sufficient to prevent the formation of a disulphide bond therebetween.

Abstract: Provided are cell culture apparatus and method. The cell culture apparatus comprises a culture column and a perfusion system, the culture column comprising a first and a second tube-connecting caps and a support for cells to attach and grow thereon. The first and the second tube-connecting caps are respectively provided with a perfusion inlet and a perfusion outlet; The perfusion system comprises a culture medium storage device, a perfusion tube and a perfusion pump. A complete and closed culture column is formed in the cell culture device after the cells are inoculated, and the culturing is completed by the perfusion system to avoid contamination.

Abstract: The present invention provides compositions, methods, and kits comprising one or more compounds of Formula I, such as XY018, alone or in combination with one or more anticancer drugs, such as an anti-androgen drug, that are useful for treating cancer, e.g., prostate cancer, such as castration-resistant prostate cancer (CRPC), and numerous other types of cancer including lung cancer, breast cancer, liver cancer, ovarian cancer, endometrial cancer, bladder cancer, colon cancer, gastric cancer, lymphoma, and glioma.

Abstract: Disclosed are a method for separately preparing light magnesium oxide and calcium oxide by using dolomite and an application thereof in preparation of a calcium-magnesium composite expanding agent. In the method for preparing light magnesium oxide and calcium oxide, based on the difference in decomposition temperature between magnesium carbonate and calcium carbonate during the calcination and decomposition of dolomite and the difference in the weight of the materials after decomposition, the effective separation of magnesium oxide and calcium oxide is realized by a one-step method, thus separately preparing light magnesium oxide and light calcium oxide. The calcium-magnesium composite expanding agent is prepared by using the foregoing light magnesium oxide and calcium oxide. On the one hand, the present invention solves the problem of the limited origin of the light magnesium oxide raw material of the magnesium expanding component in the calcium-magnesium composite expanding agent.

Abstract: Provided is an underwater repair system for a cavity region of a concrete panel rock-fill dam panel, including a moving platform, a work cabin, a pressure drainage apparatus, a traction apparatus, and a positioning apparatus; the traction apparatus controlling the movement of the moving platform on the surface of a dam concrete panel; the positioning apparatus transmits a detection position, the work cabin is a pressure cabin, the work cabin being connected to the pressure drainage apparatus, and a drill apparatus and grouting apparatus being arranged in the work cabin; the moving platform moves into the cavity region, and the pressure drainage apparatus starts up to drain the water in the work cabin, a partially closed waterless space being formed inside the work cabin, the drill apparatus drilling the concrete panel at the upper end of the cavity region and the grouting apparatus subsequently implementing grouting to complete the repair.

Abstract: A motor includes a stator, a rotor rotatable relative to the stator, a support member, and a circuit assembly. The circuit assembly includes a plurality of electronic components. The rotor is rotatably mounted to the support member. The stator is received in the rotor. The stator is fixed to the support member, and the support member is at least partially received in an inner side of the stator. A portion of the support member received in the inner side of the stator defines a receiving space, and at least part of the electronic components of the circuit assembly is received in the receiving space of the support member. The support member is partially received in the inner side of the stator, and the circuit assembly is at least partially received in the support member, which makes the motor have a relatively smaller axial size.

Abstract: The present application discloses a data processing method and apparatus. A specific implementation of the method includes: receiving floating point data sent from an electronic device; converting the received floating point data into fixed point data according to a data length and a value range of the received floating point data; performing calculation on the obtained fixed point data according to a preset algorithm to obtain result data in a fixed point form; and converting the obtained result data in the fixed point form into result data in a floating point form and sending the result data in the floating point form to the electronic device. This implementation improves the data processing efficiency.

Abstract: Disclosed is an amphiphilic multifunctional hybrid nanoparticle. The nanoparticle of the present invention has a detachable hydrophilic organic polymer with both a water-soluble long chain and a hydrophobic long hydrocarbon functional group attached to the surface, wherein the body of the nanoparticle is a silica or an organofunctional group substituted silica or an organofunctional group substituted silicon-oxygen bond network, and the nanoparticle contains a free organosiloxane with hydrophobic long hydrocarbon functional groups and a fatty acid or fatty acid ester or aluminum complex of fatty acid with hydrophobic long hydrocarbon functional groups.

Abstract: A hybridoma cell stain and a monoclonal antibody secreted therefrom and application thereof belong to the technical field of prevention and treatment of Trichinella spiralis (T. spiralis). Aiming at the technical problem of how to specifically diagnose trichinellosis, the disclosure provides a hybridoma cell strain deposited under an accession number of CGMCC No. 18317. Tests show that the monoclonal antibody Ts-ZH68-2A4-Ab secreted by the hybridoma cell strain can compete with the positive serum of pigs infected with T. spiralis for binding to Ts-ZH68 antigen, and the recognition peptide is 222GVDRSATCQGDSGGP236. The monoclonal antibody of the disclosure and the Ts-ZH68 protein B cell epitope polypeptide recognized by the monoclonal antibody can be used to prepare a reagent or a vaccine for diagnosing or preventing infection of T. spiralis, laying the foundation for establishment of a serological diagnosis method of T. spiralis.

Abstract: Methods, computer program products, computer systems, and the like are disclosed that provide for scalable deduplication in an efficient and effective manner. For example, such methods, computer program products, and computer systems can include receiving a data object at an assigned node, determining whether the data object includes a sub-data object, and processing the sub-data object. The assigned node is a node of a plurality of nodes of a cluster, where the data object includes a data segment, and a signature. The signature is generated based, at least in part, on data of the data segment. The processing includes sending the sub-data object to a remote node. The remote node is another node of the plurality of nodes of the cluster.

Abstract: Techniques for searching documents are described. An exemplary method includes receiving a document search query; querying at least one index based upon the document search query to identify matching data; fetching the identified matched data; determining one or more of a top ranked passage and top ranked documents from the set of documents based upon one or more invocations of one or more machine learning models based at least on the fetched identified matched data and the document search query; and returning one or more of the top ranked passage and the proper subset of documents.

Abstract: An iridinesulfonamide compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity, pharmaceutically acceptable salts, solvates or hydrates thereof, a pharmaceutical composition, as well as use of the compound or the pharmaceutically acceptable salts, solvates or hydrates thereof, and the pharmaceutical composition thereof in treating IDH1 mutation induced cancer.

Abstract: A semiconductor device is provided, which includes an active region, a first structure, a second gate structure, a first gate dielectric sidewall, a second gate dielectric sidewall, a first air gap region, a second air gap region and a contact structure. The active region is formed over a substrate. The first and second gate structures are formed over the active region and between the first gate structure and the second gate structure are the first gate dielectric sidewall, the first air gap region, the contact structure, the second air gap region and a second gate dielectric sidewall.

Abstract: Systems and methods for implementing a cooperative security fabric (CSF) protocol are provided. According to one embodiment, an NSD of multiple NSDs participates in the dynamic construction of a CSF interconnecting the NSDs in a form of a tree, having multiple nodes each representing one of the NSDs, based on hierarchical interconnections between the NSD and directly connected upstream and downstream NSDs. A communication channel is established by a backend daemon of the NSD with a directly connected upstream node of the NSD within the CSF through which queries and replies are communicated and through which periodic keep-alive messages and responses are exchanged between the upstream node and the NSD. A CSF protocol is enforced by a forward daemon of the NSD that limits issuance of query messages to those originated by a source NSD representing an upstream node and directed to a destination NSD representing a downstream node.

Abstract: A method, device and system for calculating a microcirculation indicator are provided. A method includes: injecting a vasodilator and subjecting a blood vessel to be measured to coronary angiography; selecting at least one angiographic image of a first body position when the blood vessel to be measured is in a resting state and an angiographic image of a second body position when the blood vessel to be measured is in a dilated state; obtaining a three-dimensional coronary artery vascular model by three-dimensional modeling; injecting a contrast agent, and obtaining time T1 taken for the contrast agent flowing from an inlet to an outlet of the segment of blood vessel and time T2 taken for the contrast agent flowing from an inlet to an outlet of the segment of blood vessel; obtaining the microcirculation indicator.

Abstract: The disclosure relates to color-changing fabric capable of transmitting patterns and characters, comprising a surface layer of cloth, a bottom layer of cloth and a middle layer which connects the surface layer of cloth and the bottom layer of cloth. Distinguished from the prior art, the disclosure provides the color-changing fabric which transmits different patterns or characters at different angles. The color of the yarns on one side or the other side of the middle layer can be seen via the stripe or mesh surface cloth, and viewed from the same side, the color of the yarns of the jacquard patterns is different from the colors of other yarns.

Abstract: Provided is a method of preparation of (1R, 3S)-3-amino-1-cyclopentanol, the method including: contacting N-acylhydroxyamine and cyclopentadiene for an asymmetric cycloaddition, to yield a first intermediate I; hydrogenating the first intermediate I to yield a second intermediate II; hydrolyzing, ammonolyzing, hydrazinolyzing, or alcoholyzing an amido bond of the second intermediate II to yield a third intermediate III; and hydrogenating the third intermediate III to yield (1R, 3S)-3-amino-1-cyclopentanol.

Abstract: Embodiments of the present disclosure disclose a method and apparatus for displaying an interface. A specific embodiment of the method comprises: acquiring device related information of a connected device; querying display interface information corresponding to the device related information of the connected device; and displaying a corresponding interface based on the display interface information. According to the embodiment, a smart terminal can display the corresponding interface according to the connected device, thereby improving the efficiency of acquiring the information by the user.